CURRENT RESEARCH PROJECTS

TBTC Study 31. A5349: Rifapentine-containing treatment shortening regimens
for pulmonary tuberculosis: A randomized, open-label, controlled phase 3 clinical trial (2015-2019). Sponsor: CDC/UCSF

This phase 3 clinical trial aims to evaluate the efficacy of a Rifapentine-containing regimens to determine whether the single substitution of rifapentine for rifampin or in addition substitutes moxifloxacin for ethambutol and continues moxifloxacin during the continuation phase would be able to shorten treatment duration of drug susceptible pulmonary tuberculosis to 17 weeks.

Sub-Study: Population Pharmacokinetic and Pharmacodynamic Study of Efficacy and Safety of High-Dose Rifapentine and Moxifloxacin for Treatment of Tuberculosis in the Study 31 Treatment Trial: Intensive PK Sampling (2016-2020). Sponsor: CDC/UCSF
This sub-study is nested with Study 31.A5349 to 1) Characterize the population pharmacokinetics of rifapentine and 25-desacetyl rifapentine, using sparse PK data from Study 31 and intensive PK data from Study 31 PK/PD; and to 2) Examine the relationship between rifapentine PK parameters of interest and treatment efficacy.

An Observational Study of Individuals Treated for Pulmonary Tuberculosis (TB) (2016-2020). Sponsor: CDC/UCSF
This observational study is a platform study aims to 1) Determine the optimal methods for identification and quantification of M. tuberculosis (MTB) in sputum over the course of TB treatment; 2) Assess outcomes of TB treatment (treatment failure, cure, relapse and death) in a rigorous and standardized manner; 3) Assess sputum parameters as surrogate markers for outcomes of TB treatment.

SELECTED PAST RESEARCH PROJECTS

Evaluation of a decade of DFID and World Bank supported HIV and AIDS programmes in Vietnam, from 2003-2012 (2012-2014). Sponsor: UK Department for International Development (DFID)
This research project evaluated the implementation, impacts, and cost-effectiveness of the 10-year HIV prevention project in Vietnam utilizing multiple datasets.

Using participatory action research to engage children with disabilities and their families in developing health initiatives to improve their access to health and social services 2010-2011). Sponsor: Wellcome Trust
This project sought to engage young people with disabilities and their families in a research study that aimed to understand the needs for health care and social services amongst children with disabilities in an Agent Orange affected area in central Vietnam.

Building the capacity in HIV/AIDS data use for government agencies in Vietnam (2010-2011). Sponsor: USAID via Abt Associates Inc.
This study aimed to build the capacity for the government healthcare agencies in the use of routinely collected and research data to support evidence-based program and policy development in HIV prevention, care and treatment in Vietnam.

Evaluation of the positive prevention project (2011). Sponsor: USAID via Abt Associates Inc.
This project assessed the effectiveness of two positive prevention models for people living with HIV/AIDS in Hanoi, Ho Chi Minh city, Hai Phong and An Giang provinces and identified factors affecting the effectiveness of the program through interview with clients, peer educators and local project staff in order to make recommendations on which model should be scaled up which components of the models should be modified.

Development of Guidelines for implementation and management of the national program in response to climate changes (2010 – 2011). Sponsor: UNDP via the Institute of Hydrometeorology and Environmental Science in the project “Strengthening national capacity to respond to climate change in Vietnam, to mitigate and control greenhouse gas emissions”
CPAS was contracted to develop Guidelines for implementation and management of the National Program to respond to climate change in Vietnam.

Evaluation of the project to develop reproductive health capacity of the commune health network in Da Nang city and Khanh Hoa provinces, Vietnam (2007-2009). Sponsor: World Bank via Global Development Network
The purpose of this project was to conduct an independent evaluation of a 3-year healthcare intervention projects on the quality and utilization of reproductive health services associated with a Social Franchised trials at commune health stations in Vietnam.

Urbanization and youth health risk behavior in Vietnam – A needs assessment study (2007-2009). Sponsor: University of Queensland

This study explored risky behaviors among young people from newly urbanized areas in major cities in Vietnam.

Gathering input from youth MSM and other young men (2007-2008). Sponsor: Save the Children USA
This study sought to understand the vulnerabilities of young gay men in Hanoi Vietnam and gathered their input in developing culturally sensitive education programs.

Mass media and sexuality among young people in Hanoi, Vietnam (2006-2007). Sponsor: Rockefeller Foundation
This study sought to understand sexual identity, relationships, and practice among emerging adults in Vietnam in conjunction with the widespread use of electronic media as a result of rapid socioeconomic development in the country.